12 Panel Drug Test – What Shows Up ?

What Shows Up on a 12 Panel Drug Test

The 12 panel drug test is one of the most sought-after drug testing supplies in the market today. It’s fast, accurate, portable, cost-effective, and simple to use. The question is – what shows up on a 12 panel drug test? What drugs does this test typically detect?

Read on and find out.

What drugs show up on a 12 panel drug test?

There are two types of 12 panel drug tests – cups and dip cards. They both test twelve different types of drugs simultaneously.

However, not all 12 panel drug screens are created equal. They come in different configurations. However varied they may be, 12 panel tests can screen for the drugs listed below.

Alcohol (EtG)

Although alcohol is not as addictive as other drugs, it is the most abused globally. In the US alone, an estimated 15 million people are suffering from alcohol addiction at some levels.

However, the authorities do not classify it as a scheduled substance. 

The effects of alcohol on the mind and body are also notable. It can multiply the amount of dopamine in the brain’s reward system by up to 360 percent.

Alcohol also affects the Central Nervous System. This can make withdrawal excruciating and even deadly. It may be legal, but it’s still hazardous when not enjoyed responsibly.

Amphetamines (AMP)

AMP is a type of stimulant that gives its users a boost in mood and energy. This general class of narcotics is a favorite of people facing tight deadlines.

Many varieties increase both focus and vigor. They’re relatively safe when taken at the medically prescribed dosages. However, higher amounts can quickly become addictive. 

As users become accustomed to their effects, they’ll need more AMP to achieve and preserve their high. Users also describe crashes when coming off amphetamines as being rather intense than their previous euphoria. This usually prompts them to start the cycle over again.

Barbiturates (BAR)

These depressants were once used as a common treatment for anxiety sleep aids. They produce a calming euphoric sensation giving them the nickname Downers. However, like several other highly addictive substances, tolerance can build up quickly. This led most modern doctors to prescribe different drugs in their place.

In addition, Barbiturates can also have withdrawal symptoms such as seizures, vomiting, and an increase in anxiety. All in all, barbiturates’ withdrawal effects can prove quite deadly as they also affect the Central Nervous System.

Buprenorphine (BUP)

Buprenorphine is a prescribed medication approved by the Food and Drug Administration (FDA) to treat Opioid Use Disorder (OUD).

BUP is an opioid partial agonist. At low to moderate doses, a user can feel euphoria and slight respiratory depression.

However, due to its opioid effects, BUP can be misused by people who are not undergoing treatment for opioid disorders.

Benzodiazepines (BZO) 

Also known as Benzos, these drugs affect the body’s neurotransmitters, giving users a mellowed experience. 

Xanax, Klonopin, and Valium are some of the most popular Benzos.

Doctors typically prescribe these drugs to help people who suffer from anxiety, stress, or panic attacks.

Moreover, those who use them regularly can also quickly develop a tolerance for them. This leads to increased dosages. Therefore, dependence comes as a consequence of long-term use.

Withdrawal can be quite severe and even fatal if medical help is not readily available.

Cocaine (COC)

Whether it’s crack or powder, cocaine can be highly addictive, with nearly one in five people who try it becoming hooked. 

Despite the ease with which dependence can occur, it remains a popular party drug.

Cocaine affects the brain’s pleasure centers while hindering these areas’ natural processors, reinforcing the need for this drug.

The effects of cocaine are relatively short. The harsh comedown that users experience often motivates them to use more to avoid the side effects. This worsens the dependence and the likelihood of an overdose.

Methamphetamine (MAMP) 

Whether they come in crystals or powdered form, meth offers its users a potent reaction. It provides powerful boosts of energy and focus to its users.

Meth stimulates the brain’s parts that create dopamine and norepinephrine.  This can permanently damage its ability to produce these neurotransmitters on its own. As a result, users feel the need for more meth to feel any pleasure.

Withdrawal from meth can be quite challenging.

Methylenedioxymethamphetamine (MDMA)

MDMA is a synthetic drug that’s more popularly known as Ecstasy or Molly. The world’s most popular entactogen is a type of psychoactive drug that affects a user’s emotions. It provides a sense of positive personal and interpersonal changes. That’s why it’s one of the most famous club drugs. 

Ecstasy abuse can lead to the following side effects:

  • impulsiveness and anxiety
  • irritability and aggression
  • depression and sleep problems
  • memory and attention problems
  • decreased appetite
  • decreased interest in and pleasure from sex
  • temperature spikes

Alarmingly, temperature spikes can cause the heart, lungs, liver and kidneys to fail. This can lead to fatal consequences.

Methadone (MTD)

Methadone is an opioid commonly used to treat addiction to more potent, more addictive opioids like heroin. Its abuse does not lead to physical addiction. However, it still affects the brain. This creates a psychological dependency that’s difficult to kick without proper structure. Withdrawal symptoms that can last more than a month.

Although medical facilities typically regulate its use, on the street, there are no such restrictions. Methadone’s popularity with those who’ve experienced it in rehab can lead to further addiction.


Opiates are a class of depressants that include heroin, morphine, opium, codeine, and methadone. They artificially activate the endorphin receptors in the brain.

Endorphins are the brain’s natural pain killers. Long-term use of opiates can reduce the body’s natural production of painkilling neurotransmitters. This usually leads to chronic pain. When this happens, the cycle begins again, often turning into dependence.

Oxycodone (OXY) 

Oxycodone, a substance that comes from the poppy plant, is the active chemical in many pain relievers like Oxycontin. 

It binds to nerve receptors in the brain and blocks pain signals.

Originally, oxycodone was intended as a safer painkilling alternative to heroin and morphine.

However, long-term use of oxycodone can lead to addiction. People who use this drug often increase their dosage because they develop a tolerance for it. 

Dependence and addiction are a couple of the side effects of oxycodone abuse. Other side effects include:

  • loss of appetite
  • dizziness
  • fatigue
  • dry mouth

Phencyclidine (PCP)

Phencyclidine or PCP is a synthetic hallucinogenic or dissociative drug. It is considered one of the most dangerous illicit substances in the current list of drugs of abuse. Although it was developed as a general anesthetic drug, its medical usage was discontinued. Why? It’s due to its addictive nature and negative side effects.

Additionally, Phencyclidine affects the functioning of the brain receptors. These receptors play a role in one’s perception of pain, emotion, memory, and learning abilities. PCP also triggers the neurotransmitter dopamine. This is responsible for the euphoria experienced with drug use.

Tetrahydrocannabinol (THC)

THC or Tetrahydrocannabinol is one of the 113 cannabinoids found in cannabis. It’s the substance responsible for the psychological effects of Marijuana and CBD.

When someone smokes or takes marijuana orally, THC attaches to the cannabinoid receptors in the brain. These are located in the areas of the brain associated with learning, memory, pleasure, and time orientation.

The euphoric effects that marijuana is known for come as a consequence.

Some effects of THC

  • Shortened memory
  • Impaired capacity for learning
  • Behavioral disorders

In addition, some people use CBD or Cannabidiol as an herbal supplement to help manage pain and epilepsy.

Some medical practitioners, on the other hand, prescribe medical marijuana for these purposes and more.  

Tricyclic Antidepressants (TCA)

TCA stands for tricyclic antidepressants. Doctors recommend this prescription drug for major depressive disorder (MDD).

Tricyclic Antidepressants are legal prescription medications. As a result, anybody who has a prescription can buy it anywhere.

Although these substances are not addictive, users develop a resistance for it. Later on, they become dependent on it.

This dependence, unfortunately, has led to fatal overdoses in the US.

Who Are Using 12 Panel Drug Tests?

  • Employers who want to ensure a drug-free workplace
  • Clinics, rehabs, hospitals, drug treatment facilities
  • Toxicology labs
  • Probationary offices, police stations, prisons

Do you want to learn more about what shows up on a 12 panel drug test? Visit the 12 Panel Now Blog. We have a wealth of information you can benefit from.

Back to list

Leave a Reply