Fentanyl

Fentanyl is an opioid analgesic that is used as a surgical anesthetic in 70% of all surgeries in the U.S. It is similar to morphine but is approximately 50-100 times more powerful. It binds to the opioid receptors in the brain in the areas that control pain and emotions. It is water soluble and is composed40 of carbon, hydrogen, nitrogen and oxygen, with a chemical formula or C22H28N2O.

Many hospitals prefer to use fentanyl because it acts fast, but it also became a popular street drug especially for cutting heroin which is much more expensive. Fentanyl is given to patients of all ages, young and old and has few undesirable side effects when used properly under strict medical supervision.

From a workplace perspective, experts believe that the misuse and abuse of fentanyl among employees in safety and security sensitive positions is a growing concern. As a pain reliever, it can be prescribed to manage moderate to severe pain, especially chronic pain. With prescriptions for fentanyl rising and with prescription drug abuse already a major concern for employers, one would think this drug would have long been a standard part for workplace drug testing. In reality, it is only requested under special situations and is therefore an extra cost for employers.

Screening Cut-Off and Detection Time
In drug screening, the cut-off level is the minimum amount of drug residue that must be found in the sample in order for the specimen to be labeled positive. It is important to remember that a negative sample does not necessarily mean that it is drug-free, only that it contains a drug at a concentration that is below the established cut-off levels.

Screening Cut-Off Level Confirmatory Test Detection Period
200 ng/ml 200 ng/ml up to 3 days from last doseDEA Drug Class
The Drug Enforcement Administration implements the Controlled Substance Act and sees to the prosecution of violators. The CSA is the U.S. drug policy that regulates the use, possession, distribution, manufacture and importation of certain narcotics, depressants, stimulants, hallucinogens, anabolic steroids and other chemicals. The CSA defines 5 schedules of drug classification (I–V) based on their abuse potential, safety and medical applications.

Fentanyl falls under Schedule II – drugs and other substances that a have high potential for abuse; are currently accepted in the United States for use in medical treatment with severe restrictions; and those, the abuse of which may lead to severe physical and/or psychological dependence.

Drug Type
Fentanyl is an opioid (painkillers). Opioids are prescription-only drugs typically given to patients to relieve severe pain from recent surgery. Under normal use, opioids break down and attach to opioid receptors in the brain. The effect is that the person’s perception of pain is reduced. Misuse and abuse of opioids affect the brain in such a way that the person experiences relaxation and euphoria.

Forms and Routes of Administration
Doctor-prescribed fentanyl often comes in any of the following forms:

Transdermal patches
Injections
Buccal lozenges/soluble film
Nasal spray/inhaler
Sublingual spray
Tablets or lollipops
Pharmaceutical fentanyl also ends up in the streets or in the hands of unauthorized users. For example, the gel from transdermal patches may be swallowed or injected. The kind of fentanyl (or its analogs) that underground manufacturers make for trafficking in the streets comes in any of the following forms:

Powder (usually cut into heroin) – for snorting, smoking, swallowing or rubbing onto gums
Laced on blotter paper – for absorption through the mucous membrane in the mouth
Tablets – for swallowing
Ways Fentanyl is Trafficked

Brand Names
Subsys (sublingual spray)
Sublimaze® (injection)
Onsolis (buccal soluble film)
Lazanda (nasal spray)
Ionsys (transdermal device)
Fentora™ (buccal tablet)
Duragesic® (transdermal patch)
Actiq® (lozenge or lollipop)
Abstral (sublingual tablet)
Medical Uses for Fentanyl
Anesthesia during surgery
For the relief of pain before, during and after surgery
For the relief and management of severe ongoing pain from cancer and other terminal illnesses
For the relief of chronic pain from other medical conditions for people who are physically tolerant of other opioids
Recreational Uses of Fentanyl
To achieve heroin-like euphoria
To experience a long-lasting high
To cut pure heroin
To increase potency of low-quality heroin
Recreational Uses of Fentanyl

Street Names for Fentanyl
TNT
Tango and Cash
Poison
Perc-a-Pop
Murder 8
King Ivory
Jackpot
He-Man
Great Bear
Goodfellas
Friend
Dance Fever
China White
China Town
China Girl
Apache
Fentanyl Side Effects
When opioids bind to the brain’s opioid receptors, dopamine levels in the brain’s reward areas rise. This is what causes the intense relaxation and euphoria. There are opioid receptors in the areas of the brain that control our breathing rate as well, and if high doses of potent opioids like fentanyl find their way to these receptors, breathing can stop completely, leading to death.

Because of fentanyl’s direct effect on the brain, it may also lead to psychological problems that include but are not limited to:

Depression
Crying spells
Suicidal thoughts
Behavioral changes affecting sleep and appetite
Irritability
Anxiety
Hallucinations
Fentanyl Side Effects

Short Term Effects of Fentanyl
The short term effects of fentanyl include relief from pain, relaxation and euphoria, but the side effects are far more numerous:

Altered heart rate
Confusion
Constipation
Constricted pupils
Hallucinations
Itchy skin
Nausea
Seizures
Slowed breathing rate (high doses can cause breathing to stop altogether)
Sweating
Vomiting
Weakness

Long Term Effects of Fentanyl
Sustained fentanyl use and abuse can have long term psycho-social effects including:

Tolerance
Addiction
Higher risk of overdose and death
Poor judgment in personal and professional situations/relationships
Damage to body tissues and organs from oxygen deprivation
Trigger or worsen pre-existing mental health conditions
Worsen depression
The DEA believes that medical fentanyl gets diverted for illegal uses through medical workers who steal the drug from hospitals, falsify medical records, and even go as far as to pull fentanyl patches off a patient. Illegal fentanyl in the streets today are meant to enhance low-quality heroin and are mostly made in Mexican laboratories.

Fentanyl Dependence
Due to the high potency of fentanyl, tolerance to the drug sets in faster, necessitating higher and higher doses to achieve the same effect. This risk of dependence is high for anyone, regardless of whether fentanyl use is for a legitimate medical condition or recreational only. A sure sign of dependence is when a person begins to experience the following withdrawal symptoms after attempting to stop using:

Agitation
Anxiety
Diarrhea
Fever and chills
Intense drug cravings
Loss of appetite
Nausea and vomiting
Panic attacks
Runny nose
Sweating
Tremors
History of Fentanyl
Seized Fentanyl Product Statistics

Dr. Paul Janssen of Janssen Pharmaceutica was the first to develop Fentanyl under a patent held by his company in 1959. Being the strong analgesic that it was, the medical field quickly adopted it for use as an anesthetic and post-surgical pain reliever.

By the 1960s, Sublimaze® was introduced as an intravenous anesthetic. Its popularity paved the way for the development of fentanyl analogues that included Lofentanil, Alfentanil, Remifentanil and Sufentanil.

The mid-1970s saw the first illicit use of pharmaceutical fentanyl and its analogues by members of the medical community – nurses, doctors, anesthesiologists and other medical health workers. They would draw fentanyl out from vials and replace it with a saline solution. Late into the decade, Fentanyl made its way into the streets with China White and became a popular street drug on the west coast by the 1980s. It was also around the same time that fentanyl was introduced to the club scene in New York.

In the mid-1990s, the fentanyl patch (Duragesic) was developed. It can be worn on the skin and was used for managing chronic pain in cancer patients. It provides long-term pain relief, usually 2-3 days and remains to be the most widely-used form of fentanyl delivery. Soon, oral preparations containing fentanyl citrate with fillers were developed, including the buccal tablet Fentora and the Actiq lollipop. The Actiq lollipop was introduced for young cancer patients, but this form also became popular with club parties and all-nighters.

In 2013, illegally manufactured fentanyl rates went up. It is believed that criminal organizations were behind the increase in global supplies of fentanyl precursor chemicals, resulting in the increase of trafficked products onto the streets. To illustrate this, the number of seized fentanyl products in 2014 was 5,343. By 2015, this number rose to 15,882 – almost 300% increase.

2016 saw a 326% increase in opioid overdose deaths from the previous decade and a 1000% increase from 1990. Fentanyl abuse has become such a problem in Canada that British Columbia declared a state of emergency.

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RELATED READINGS
6-MAM, Fentanyl & Carfentanil Drug Information

http://www.news-medical.net/health/Fentanyl-History.aspx

Fentanyl Addiction

http://www.encyclopedia.com/science/applied-and-social-sciences-magazines/fentanyl

http://www.npr.org/sections/health-shots/2016/08/25/491340448/illegally-made-fentanyl-seems-to-be-driving-a-spike-in-overdoses

http://www.testcountry.com/wiki/opioids-abuse-signs-symptoms-testing.html

https://www.drugs.com/csa-schedule.html

http://www.fda.gov/regulatoryinformation/legislation/ucm148726.htm

Opioids, Depressants and Stimulants: What’s the Difference?

https://www.drugabuse.gov/publications/drugfacts/fentanyl

http://www.livestrong.com/article/143836-psychological-effects-fentanyl/

The Effects of Fentanyl Use

http://www.npr.org/sections/health-shots/2016/08/25/491340448/illegally-made-fentanyl-seems-to-be-driving-a-spike-in-overdoses

For Further Reading:

http://mentalhealthdaily.com/2015/11/16/how-long-does-fentanyl-stay-in-your-system/

http://www.medicinenet.com/fentanyl_tablet_-_buccal/article.htm

https://en.wikipedia.org/wiki/Fentanyl#History

http://www.npr.org/sections/health-shots/2015/08/26/434867357/how-the-prescription-painkiller-fentanyl-became-a-street-drug

https://www.deadiversion.usdoj.gov/drug_chem_info/fentanyl.pdf