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Fentanyl

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Fentanyl

What is Fentanyl?

See also: Fentanyl – What You Need to Know – Answers from 12 Panel Now

Fentanyl is an opioid analgesic that is used as a surgical anesthetic in 70% of all surgeries in the U.S. It is similar to morphine but is approximately 50-100 times more powerful. It binds to the opioid receptors in the brain in the areas that control pain and emotions. It is water-soluble and is composed of 40 of carbon, hydrogen, nitrogen, and oxygen, with a chemical formula of C22H28N2O.

Many hospitals prefer to use fentanyl due to its fast action and potency.  It’s prescribed to patients of all ages, young and old and has few undesirable side effects, as well as few instances of addiction when used properly under strict medical supervision.

From a workplace perspective, experts believe that the misuse and abuse of fentanyl among employees in safety and security-sensitive positions is a growing concern. As a pain reliever, it can be prescribed to manage moderate to severe pain, especially chronic pain. With prescriptions rising and with prescription drug abuse already a major concern for employers, one would think this drug would have long been a standard part for workplace drug testing. In reality, it is only requested under special situations and is, therefore, an extra cost for employers.

Screening Cut-Off and Detection Time

In drug screening, the cut-off level is the minimum amount of drug residue that must be found in the sample in order for the specimen to be labeled positive. It is important to remember that a negative sample does not necessarily mean that it is drug-free, only that it contains a drug at a concentration that is below the established cut-off levels.

Screening Cut-Off Level Confirmatory Test Detection Period

200 ng/ml 200 ng/ml up to 3 days from last dose DEA Drug Class

The Drug Enforcement Administration implements the Controlled Substance Act and sees the prosecution of violators. The CSA is the U.S. drug policy that regulates the use, possession, distribution, manufacture, and importation of certain narcotics, depressants, stimulants, hallucinogens, anabolic steroids and other chemicals. The CSA defines 5 schedules of drug classification (I–V) based on their abuse potential, safety, and medical applications.

Fentanyl falls under Schedule II – drugs and other substances that have a high potential for abuse; are currently accepted in the United States for use in medical treatment with severe restrictions; and those, the abuse of which may lead to severe physical and/or psychological dependence.

Drug Type

Fentanyl is an opioid (painkillers). Opioids are prescription-only drugs typically given to patients to relieve severe pain from recent surgery. Under normal use, opioids break down and attach to opioid receptors in the brain. The effect is that the person’s perception of pain is reduced. Misuse and abuse of opioids affect the brain in such a way that the person experiences relaxation and euphoria.

Forms and Routes of Administration

Doctor-prescribed fentanyl often comes in any of the following forms:

Transdermal patches

  • Injections
  • Buccal lozenges/soluble film
  • Nasal spray/inhaler
  • Sublingual spray
  • Tablets or lollipops

Pharmaceutical fentanyl also ends up in the streets or in the hands of unauthorized users. For example, the gel from transdermal patches may be swallowed or injected. The kind of fentanyl (or its analogs) that underground manufacturers make for trafficking in the streets comes in any of the following forms:

Powder (usually cut into heroin) – for snorting, smoking, swallowing or rubbing onto gums
Laced on blotter paper – for absorption through the mucous membrane in the mouth
Tablets – for swallowing
Ways Fentanyl is Trafficked

Brand Names

  • Subsys (sublingual spray)
  • Sublimaze® (injection)
  • Onsolis (buccal soluble film)
  • Lazanda (nasal spray)
  • Ionsys (transdermal device)
  • Fentora™ (buccal tablet)
  • Duragesic® (transdermal patch)
  • Actiq® (lozenge or lollipop)
  • Abstral (sublingual tablet)

Medical Uses

Anesthesia during surgery

  • For the relief of pain before, during and after surgery
  • For the relief and management of severe ongoing pain from cancer and other terminal illnesses
  • For the relief of chronic pain from other medical conditions for people who are physically tolerant of other opioids
  • Recreational Uses of Fentanyl
  • To achieve heroin-like euphoria
  • To experience a long-lasting high
  • To cut pure heroin
  • To increase the potency of low-quality heroin
  • Recreational Uses of Fentanyl

Street Names 

  • TNT
  • Tango and Cash
  • Poison
  • Perc-a-Pop
  • Murder 8
  • King Ivory
  • Jackpot
  • He-Man
  • Great Bear
  • Goodfellas
  • Friend
  • Dance Fever
  • China White
  • China Town
  • China Girl
  • Apache

Side Effects

When opioids bind to the brain’s opioid receptors, dopamine levels in the brain’s reward areas rise. This is what causes the intense relaxation and euphoria. There are opioid receptors in the areas of the brain that control our breathing rate as well, and if high doses of potent opioids like fentanyl find their way to these receptors, breathing can stop completely, leading to death.

Because of fentanyl’s direct effect on the brain, it may also lead to psychological problems that include but are not limited to:

Depression

  • Crying spells
  • Suicidal thoughts
  • Behavioral changes affecting sleep and appetite
  • Irritability
  • Anxiety
  • Hallucinations

Fentanyl Side Effects

Short Term Effects of Fentanyl

The short term effects include relief from pain, relaxation, and euphoria, but the side effects are far more numerous:

  • Altered heart rate
  • Confusion
  • Constipation
  • Constricted pupils
  • Hallucinations
  • Itchy skin
  • Nausea
  • Seizures
  • Slowed breathing rate (high doses can cause breathing to stop altogether)
  • Sweating
  • Vomiting
  • Weakness

Long-Term Effects of Fentanyl

Sustained fentanyl use and abuse can have long-term psycho-social effects including:

  • Tolerance
  • Addiction
  • Higher risk of overdose and death
  • Poor judgment in personal and professional situations/relationships
  • Damage to body tissues and organs from oxygen deprivation
  • Trigger or worsen pre-existing mental health conditions
  • Worsen depression

The DEA believes that medical fentanyl gets diverted for illegal uses through medical workers who steal the drug from hospitals, falsify medical records, and even go as far as to pull fentanyl patches off a patient. Illegal fentanyl in the streets today are meant to enhance low-quality heroin and are mostly made in Mexican laboratories.

Fentanyl Dependence

Due to the high potency of fentanyl, tolerance to the drug sets in faster, necessitating higher and higher doses to achieve the same effect. This risk of dependence is high for anyone, regardless of whether it’s used is for a legitimate medical condition or recreational only. A sure sign of dependence is when a person begins to experience the following withdrawal symptoms after attempting to stop using:

  • Agitation
  • Anxiety
  • Diarrhea
  • Fever and chills
  • Intense drug cravings
  • Loss of appetite
  • Nausea and vomiting
  • Panic attacks
  • Runny nose
  • Sweating
  • Tremors

History of Fentanyl

Seized Fentanyl Product Statistics

Dr. Paul Janssen of Janssen Pharmaceutica was the first to develop Fentanyl under a patent held by his company in 1959. Being the strong analgesic that it was, the medical field quickly adopted it for use as an anesthetic and post-surgical pain reliever.

By the 1960s, Sublimaze® was introduced as an intravenous anesthetic. Its popularity paved the way for the development of fentanyl analogues that included Lofentanil, Alfentanil, Remifentanil, and Sufentanil.

The mid-1970s saw the first illicit use of pharmaceutical fentanyl and its analogues by members of the medical community – nurses, doctors, anesthesiologists, and other medical health workers. They would draw fentanyl out from vials and replace it with a saline solution. Late into the decade, it made its way into the streets with China White and became a popular street drug on the west coast by the 1980s. It was also around the same time that fentanyl was introduced to the club scene in New York.

In the mid-1990s, the fentanyl patch (Duragesic) was developed. It can be worn on the skin and was used for managing chronic pain in cancer patients. It provides long-term pain relief, usually 2-3 days and remains to be the most widely-used form of fentanyl delivery. Soon, oral preparations containing fentanyl citrate with fillers were developed, including the buccal tablet Fentora and the Actiq lollipop. The Actiq lollipop was introduced for young cancer patients, but this form also became popular with club parties and all-nighters.

In 2013, illegally manufactured fentanyl rates went up. It is believed that criminal organizations were behind the increase in global supplies of fentanyl precursor chemicals, resulting in an increase of trafficked products onto the streets. To illustrate this, the number of seized fentanyl products in 2014 was 5,343. By 2015, this number rose to 15,882 – almost 300% increase.

2016 saw a 326% increase in opioid overdose deaths from the previous decade and a 1000% increase from 1990. Fentanyl abuse has become such a problem in Canada that British Columbia declared a state of emergency.

Can I Purchase a Single Use Drug Test for Fentanyl?

12 Panel Now offers Drug Tests in Bulk, or for single use. If you are concerned about how someone will fare on a Drug Test, or simply wish to test yourself, it’s a fairly easy process taking only a few minutes.  Our Single Use 12 Panel Urine Drug Test tests for 12 commonly abused drugs, including Fentanyl.

After the donor seals the urine in the leak-proof container, it is then handed off to the evaluator.  What makes the process streamlined is that the strips used to indicate the test results are sealed within the container.  For hygiene reasons, this is ideal. When it is time to view the test results, the evaluator simply peels away the outside label revealing the drug test strips with each individual result.

The test results within the Drug Test will show results within a few minutes.  Results should be evaluated within 5-8 minutes. Results should not be evaluated after 1o minutes.

The 12 Panel Drug Testing Kits are designed to detect 12 of the most abused and commonly used drugs. However, depending on your needs, you can purchase other kits that test for different drugs.  For instance, the 13 Panel Drug Testing Cup includes all the same drugs tested within a 12 Panel Drug Test with the addition of the drug Fentanyl (FYL).  There are also variants of the typical 12 Panel Drug Test that include drugs like phencyclidine, or PCP.

If you have any questions or concerns regarding our product or wish to place an order, feel free to call us at (888) 936-6627

6-MAM, Fentanyl & Carfentanil Drug Information

http://www.news-medical.net/health/Fentanyl-History.aspx

http://www.encyclopedia.com/science/applied-and-social-sciences-magazines/fentanyl

http://www.npr.org/sections/health-shots/2016/08/25/491340448/illegally-made-fentanyl-seems-to-be-driving-a-spike-in-overdoses

http://www.testcountry.com/wiki/opioids-abuse-signs-symptoms-testing.html

https://www.drugs.com/csa-schedule.html

http://www.fda.gov/regulatoryinformation/legislation/ucm148726.htm

Opioids, Depressants and Stimulants: What’s the Difference?

For Further Reading:

https://www.drugabuse.gov/publications/drugfacts/fentanyl

http://www.livestrong.com/article/143836-psychological-effects-fentanyl/

http://www.npr.org/sections/health-shots/2016/08/25/491340448/illegally-made-fentanyl-seems-to-be-driving-a-spike-in-overdoses

http://mentalhealthdaily.com/2015/11/16/how-long-does-fentanyl-stay-in-your-system/

https://en.wikipedia.org/wiki/Fentanyl#History

http://www.npr.org/sections/health-shots/2015/08/26/434867357/how-the-prescription-painkiller-fentanyl-became-a-street-drug

https://www.deadiversion.usdoj.gov/drug_chem_info/fentanyl.pdf

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