Drug Test

Does Cyclobenzaprine Show Up on a 12 Panel Drug Test?

Does Cyclobenzaprine Show Up on a 12 Panel Drug Test
Cyclobenzaprine is one of the top 50 prescription drugs in the US. It is a muscle relaxant in alleviating pain, tenderness, and mobility issues due to muscle spasms. Due to its popularity, some people wonder – Can Cyclobenzaprine be detected in a 12-panel drug test? Read on to know Does Cyclobenzaprine Show Up on a 12 Panel Drug Test?


Amrix, Fexmid, Flexeril, and FusePaqTabradol are the most common Cyclobenzaprine brands. It blocks nerve impulses or pain sensations that are sent to the brain.

More importantly, it does not take the place of rest, exercise, physical therapy, or other treatment that doctors recommend. Besides, it is intended for short-term use. Doctors typically prescribe it for up to two or three weeks.

Do Muscle Relaxers Show Up On a 12 Panel Drug Test?

Muscle relaxants, including commonly used drugs, are not typically detected in a standard 12-panel drug test, as these screenings primarily target controlled substances like marijuana, amphetamines, opioids, benzodiazepines, and others. Even though muscle relaxants do not usually appear on such tests, they can be detected through specific tests. For instance, Flexeril can be found in urine for 4 to 14 days, in blood for up to 10 days, and in saliva for 3 to 10 days. It’s important to note that the duration of the drug’s presence in the system can vary based on factors such as age, sex, body mass, metabolic rate, genetics, health condition, frequency of administration, dosage, and co-administered drugs

Side effects of taking Cyclobenzaprine

Taking Cyclobenzaprine may cause the following side effects.


      • Blurred vision which results to inability to see fine detail

      • Dizziness, drowsiness, or lightheadedness

    • Dryness of the mouth or xerostomia


Less common or rare side effects


      • Headache

      • Anxiety

      • Constipation

      • Frequent urination

      • Loose watery stool

      • Difficulty in speaking

      • Abdominal bloating, indigestion, nausea or vomiting

      • Malaise or general feeling of being unwell

      • Tiny muscle contractions in the body

      • Numbness, tingling, pain, or weakness in hands or feet

      • Heart palpitation

      • Shaking involuntarily

      • Unpleasant taste sensations

      • Unusual muscle weakness

      • Unusual fatigue

    • Difficulty sleeping



How long Cyclobenzaprine stays in your body

On average, it is detectable in your body within the periods listed below.


      • Blood – up to 3 days

      • Saliva – up to 36 hours

      • Urine– up to 8 days

    • Hair follicle – up to 90 days


Cyclobenzaprine has an average elimination half-life of 18 hours.

The half-life of any drug refers to the time it takes for the plasma concentration of the drug to reduce to half of its original value. Thus, the test uses this to estimate the duration of a particular drug in your body.

Older patients and those with impaired liver function take more time in eliminating Cyclobenzaprine from their bodies. Those with faster metabolism and higher body weight eliminate it more quickly. Conversely, those who use large amounts of the drug or who frequently use it will eliminate it more slowly.


Can Cyclobenzaprine be abused or misused?

In general, Cyclobenzaprine is non-addictive. However, it has a high probability of being abused with other extreme drugs. This drug depresses the central nervous system, and some people find these effects desirable, which can lead to misuse.

For instance, someone might abuse Flexeril to feel relaxed, mildly euphoric, or sedated. Used in high doses, Flexeril produces a variety of anticholinergic effects, altering brain neurotransmitters’ activity.


Why test for Cyclobenzaprine

The reasons for doing drug testing on Cyclobenzaprine are now apparent.

First, the National Institute on Drug Abuse reports that people ages 18 to 25 abuse Flexeril. Many of them use Cyclobenzaprine with other drugs to intensify alcohol, cocaine, and other drugs.

Second, the chronic use of Cyclobenzaprine can turn into an addiction. Tolerance can lead to physical dependence. Withdrawal symptoms ensue as a result of quitting.

Check out these symptoms of Flexeril addiction and abuse.


      • Takes more than what a doctor prescribes

      • Requires more of the drug to achieve the initial effect

      •  Combines Flexeril with other drugs or alcohol

      •  Continues to use Flexeril despite adverse consequences.

      •  Misses out on work, school, or social activities due to drug use

      •  Takes Flexeril for nonmedical reasons

      •  Tries to quit using Flexeril or cuts back on usage but resumes using

      •  Uses Flexeril to come down from stimulants such as cocaine, amphetamine, etc.

      •  Has difficulties with relationships as a result of Flexeril use

      •  Gets into legal trouble due to the use of Flexeril

      •  Has a financial problem due to the use of drugs

    •  Uses the drug in dangerous conditions, such as while operating a motor vehicle


Does Cyclobenzaprine Show Up on a 12 Panel Drug Test?

Now, we’re ready to answer the question we posed at the start of this blog. “Will Cyclobenzaprine be detected in a 12-panel drug test?”

No. This drug is a muscle relaxant so it doesn’t show up on a 12 panel drug test. The drug test would have to specifically test for the presence of Cyclobenzaprine.

A standard drug screening checks on the following substances:


      1. Amphetamines

      1. Barbiturates

      1. Benzodiazepines

      1. Buprenorphine

      1. Cocaine

      1. Ecstasy

      1. Marijuana

      1. Methadone

      1. Methamphetamine

      1. Morphine

      1. Oxycodone

    1. Tricyclic Antidepressants


However, patients who take Cyclobenzaprine can t`rigger a false positive result for Tricyclic Antidepressants (TCAs).  It’s because this drug is structurally and pharmacologically related to the tricyclic antidepressants.

Additionally, it is not an antidepressant and it does not have the same cardiac toxicity as the TCAs. There is little evidence that cyclobenzaprine causes liver injury.

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